*Highlighted games airing on My21
| Tue, 3/25 | Red Sox | 3:05p | L 6-5 |
| Wed, 3/26 | Red Sox | 3:05p | W 5-1 |
| Tue, 4/1 | Red Sox | 7:05p | L 2-1 |
| Wed, 4/2 | Red Sox | 7:05p | L 5-0 |
| Fri, 4/4 | Indians | 7:05p | W 6-3 |
| Sat, 4/5 | Indians | 1:05p | W 6-1 |
| Sun, 4/6 | Indians | 1:05p | L 2-1 |
| Tue, 4/8 | at Blue Jays | 4:07p | W 9-8 |
| Wed, 4/9 | at Blue Jays | 4:07p | W 6-3 |
| Thu, 4/10 | at Blue Jays | 4:07p | W 3-2 |
| Fri, 4/11 | at Indians | 4:05p | W 9-7 |
| Sat, 4/12 | at Indians | 4:05p | W 7-3 |
| Sun, 4/13 | at Indians | 10:05a | L 7-1 |
| Mon, 4/14 | at White Sox | 5:11p | W 2-1 |
| Tue, 4/15 | at White Sox | 11:05a | L 4-1 |
| Wed, 4/16 | Mariners | 7:05p | L 4-2 |
| Thu, 4/17 | Mariners | 7:05p | L 8-1 |
| Fri, 4/18 | Royals | 7:05p | W 13-2 |
| Sat, 4/19 | Royals | 4p | W 6-5 |
| Sun, 4/20 | Royals | 1:05p | W 7-1 |
| Tue, 4/22 | Twins | 7:05p | L 5-4 |
| Wed, 4/23 | Twins | 7:05p | W 3-0 |
| Thu, 4/24 | Twins | 12:35p | W 11-2 |
| Fri, 4/25 | at Mariners | 7:10p | W 4-3 |
| Sat, 4/26 | at Mariners | 6:10p | L 5-3 |
| Sun, 4/27 | at Mariners | 1:10p | W 4-2 |
| Mon, 4/28 | at Angels | 7:05p | W 14-2 |
| Tue, 4/29 | at Angels | 7:05p | L 2-0 |
| Wed, 4/30 | at Angels | 7:05p | L 6-1 |
| Thu, 5/1 | at Angels | 7:05p | W 15-8 |
| Fri, 5/2 | Rangers | 7:05p | L 4-3 |
| Sat, 5/3 | Rangers | 6:05p | L 6-3 |
| Sun, 5/4 | Rangers | 1:05p | W 3-1 |
| Mon, 5/5 | Orioles | 7:05p | W 2-1 10th |
| Tue, 5/6 | Orioles | 7:05p | W 4-2 |
| Wed, 5/7 | Orioles | 12:35p | W 6-5 10th |
| Fri, 5/9 | at Rangers | 5:05p | L 4-0 |
| Sat, 5/10 | at Rangers | 5:05p | L 6-4 |
| Sun, 5/11 | at Rangers | 12:05p | |
| Tue, 5/13 | at Indians | 4:05p | W 12-6 |
| Wed, 5/14 | at Indians | 4:05p | L 4-0 |
| Thu, 5/15 | at Indians | 9:05a | L 2-0 |
| Fri, 5/16 | at Braves | 4:35p | L 2-0 |
| Sat, 5/17 | at Braves | 4:10p | W 5-4 |
| Sun, 5/18 | at Braves | 10:35a | L 5-2 |
| Mon, 5/19 | Rays | 7:05p | L 7-6 13th |
| Tue, 5/20 | Rays | 7:05p | L 3-2 |
| Wed, 5/21 | Rays | 12:35p | W 9-1 |
| Fri, 5/23 | Red Sox | 7:05p | W 8-3 |
| Sat, 5/24 | Red Sox | 6:05p | W 3-0 |
| Sun, 5/25 | Red Sox | 1:05p | W 6-3 |
| Tue, 5/27 | Blue Jays | 7:05p | W 3-1 |
| Wed, 5/28 | Blue Jays | 7:05p | L 2-1 |
| Thu, 5/29 | Blue Jays | 12:35p | L 12-0 |
| Fri, 5/30 | at Rangers | 5:05p | L 3-1 |
| Sat, 5/31 | at Rangers | 5:05p | L 8-4 |
| Sun, 6/1 | at Rangers | 12:05p | W 13-8 |
| Mon, 6/2 | Tigers | 7:05p | W 3-2 |
| Tue, 6/3 | Tigers | 7:05p | W 5-4 11th |
| Wed, 6/4 | Tigers | 12:35p | W 10-2 |
| Fri, 6/6 | Angels | 7:05p | L 3-1 |
| Sat, 6/7 | Angels | 6:05p | L 5-3 |
| Sun, 6/8 | Angels | 1:05p | W 7-3 12th |
| Tue, 6/10 | Yankees | 7:05p | L 3-1 |
| Wed, 6/11 | Yankees | 7:05p | W 8-4 |
| Thu, 6/12 | Yankees | 7:05p | L 4-1 |
| Fri, 6/13 | at Giants | 7:15p | W 5-1 |
| Sat, 6/14 | at Giants | 6:05p | W 4-0 |
| Sun, 6/15 | at Giants | 1:05p | W 5-3 |
| Tue, 6/17 | at Diamondbacks | 6:40p | W 15-1 |
| Wed, 6/18 | at Diamondbacks | 6:40p | L 11-1 |
| Thu, 6/19 | at Diamondbacks | 12:40p | L 2-1 |
| Fri, 6/20 | Marlins | 7:05p | W 7-6 11th |
| Sat, 6/21 | Marlins | 6:05p | L 6-4 |
| Sun, 6/22 | Marlins | 1:05p | W 7-1 |
| Tue, 6/24 | Phillies | 7:05p | W 5-2 |
| Wed, 6/25 | Phillies | 7:05p | L 4-0 |
| Thu, 6/26 | Phillies | 12:35p | W 5-0 |
| Fri, 6/27 | Giants | 7:05p | W 4-1 |
| Sat, 6/28 | Giants | 6:05p | L 1-0 |
| Sun, 6/29 | Giants | 1:05p | L 11-1 |
| Mon, 6/30 | at Angels | 7:05p | W 6-1 |
| Tue, 7/1 | at Angels | 7:05p | L 5-3 |
| Wed, 7/2 | at Angels | 12:35p | L 7-4 |
| Thu, 7/3 | at White Sox | 5:11p | W 3-2 |
| Fri, 7/4 | at White Sox | 4:05p | W 7-1 |
| Sat, 7/5 | at White Sox | 4:05p | L 6-1 |
| Sun, 7/6 | at White Sox | 11:05a | L 4-3 |
| Mon, 7/7 | Mariners | 7:05p | W 4-3 |
| Tue, 7/8 | Mariners | 7:05p | W 2-0 |
| Wed, 7/9 | Mariners | 7:05p | L 6-4 |
| Thu, 7/10 | Mariners | 12:35p | W 3-2 11th |
| Fri, 7/11 | Angels | 7:05p | W 9-2 |
| Sat, 7/12 | Angels | 6:05p | L 4-1 |
| Sun, 7/13 | Angels | 1:05p | L 4-3 |
| Fri, 7/18 | at Yankees | 4:05p | L 7-1 |
| Sat, 7/19 | at Yankees | TBD | L 4-3 12th |
| Sun, 7/20 | at Yankees | 10:05a | L 2-1 |
| Mon, 7/21 | at Rays | 4:10p | L 4-0 |
| Tue, 7/22 | at Rays | 4:10p | W 8-1 |
| Wed, 7/23 | at Rays | 9:40a | L 4-3 |
| Fri, 7/25 | Rangers | 7:05p | L 14-6 |
| Sat, 7/26 | Rangers | 1:05p | L 9-4 |
| Sun, 7/27 | Rangers | 1:05p | W 6-5 |
| Mon, 7/28 | Royals | 7:05p | L 4-2 |
| Tue, 7/29 | Royals | 7:05p | L 5-2 |
| Wed, 7/30 | Royals | 12:35p | L 4-3 10th |
| Fri, 8/1 | at Red Sox | 4:05p | L 2-1 12th |
| Sat, 8/2 | at Red Sox | 4:05p | L 12-2 |
| Sun, 8/3 | at Red Sox | 10:35a | L 5-2 |
| Mon, 8/4 | at Blue Jays | 3:07p | L 6-1 |
| Tue, 8/5 | at Blue Jays | 4:07p | L 4-3 |
| Wed, 8/6 | at Blue Jays | 4:07p | L 5-1 |
| Thu, 8/7 | at Blue Jays | 4:07p | L 6-4 |
| Fri, 8/8 | at Tigers | 4:05p | W 4-2 |
| Sat, 8/9 | at Tigers | 4:05p | L 10-2 |
| Sun, 8/10 | at Tigers | 10:05a | L 6-1 |
| Tue, 8/12 | Rays | 7:05p | W 2-1 |
| Wed, 8/13 | Rays | 7:05p | L 3-2 |
| Thu, 8/14 | Rays | 12:35p | L 7-6 12th |
| Fri, 8/15 | White Sox | 7:05p | W 6-4 |
| Fri, 8/16 | White Sox | 4:00p | L 2-1 |
| Sun, 8/17 | White Sox | 1:05p | L 13-1 |
| Mon, 8/18 | at Twins | 5:10p | W 3-2 |
| Tue, 8/19 | at Twins | 5:10p | L 13-2 |
| Wed, 8/20 | at Twins | 10:10a | L 3-1 |
| Thu, 8/21 | at Mariners | 7:10p | W 2-0 |
| Fri, 8/22 | at Mariners | 7:10p | L 7-5 |
| Sat, 8/23 | at Mariners | 7:10p | W 5-1 |
| Sun, 8/24 | at Mariners | 1:10p | L 8-4 |
| Mon, 8/25 | at Angels | 7:05p | W 2-1 |
| Tue, 8/26 | at Angels | 7:05p | L 5-1 |
| Wed, 8/27 | at Angels | 7:05p | W 6-5 |
| Thu, 8/28 | Twins | 7:05p | W 3-2 |
| Fri, 8/29 | Twins | 7:05p | L 12-2 |
| Sat, 8/30 | Twins | 6:05p | W 3-2 |
| Sun, 8/31 | Twins | 1:05p | L 12-4 |
| Tue, 9/2 | at Royals | 5:10p | L 5-2 |
| Wed, 9/3 | at Royals | 5:10p | Postponed |
| Thu, 9/4 | at Royals | 10:05a | L 5-4 10th |
| Thu, 9/4 | at Royals | 5:10p | L 9-6 |
| Fri, 9/5 | at Orioles | 4:05p | W 11-2 |
| Sat, 9/6 | at Orioles | 4:05p | W 5-1 |
| Mon, 9/8 | at Tigers | 4:05p | L 14-8 |
| Tue, 9/9 | at Tigers | 4:05p | W 3-2 |
| Wed, 9/10 | at Tigers | 10:05a | W 5-2 |
| Thu, 9/11 | Rangers | 7:05p | L 6-1 |
| Fri, 9/12 | Rangers | 7:05p | L 7-0 |
| Sat, 9/13 | Rangers | 1:05p | W 7-1 |
| Sun, 9/14 | Rangers | 1:05p | W 7-4 |
| Tue, 9/16 | Angels | 7:05p | W 8-1 |
| Wed, 9/17 | Angels | 7:05p | W 3-2 |
| Thu, 9/18 | Angels | 12:35p | L 6-4 |
| Fri, 9/19 | Mariners | 7:05p | W 2-0 |
| Sat, 9/20 | Mariners | 1:05p | W 8-7 |
| Sun, 9/21 | Mariners | 1:05p | W 5-3 |
| Mon, 9/22 | at Rangers | 5:05p | W 4-3 11th |
| Tue, 9/23 | at Rangers | 5:05p | L 6-4 |
| Wed, 9/24 | at Rangers | 11:05a | L 14-4 |
| Fri, 9/26 | at Mariners | 7:10p | L 10-8 |
| Sat, 9/27 | at Mariners | TBD | L 7-3 |
| Sun, 9/28 | at Mariners | 1:10p | L 4-3 |
